WUTH publication: Neonatal IVC thrombosis in a baby born to an aPL positive mother – a case report

Citation: Lupus. 2023, 32(3), 441-43
Author: Ramakrishnan, Smriti; Abbas, Azhar; Jordan, Natasha
Abstract: Neonatal antiphospholipid syndrome (APS) is a rare condition that can occur due to either transplacental transfer of antiphospholipid antibodies (aPL) from the mother, or, more rarely, de novo in the infant.[1] The condition manifests as arterial, venous or mixed thromboses. In the present case, the mother had gestational hypertension, which may have acted as a risk factor for foetal thrombosis.[9] Although maternal hypertension has been found to be independently associated with foetal arterial thrombosis,[10] no such association has been found with venous thrombosis. In the present case, it is possible that gestational hypertension in combination with aPLs resulted in the formation of the IVC thrombosis, but further study is required to determine whether there is a consistent association between maternal hypertension and neonatal venous thrombosis. [Extracted from the article]