Tracking

Thursday 27 April 2017

Now recruiting! Trust-wide Randomised Chocolate Trial

If you like the idea of testing the effects of chocolate consumption, come along and take part in a Randomised Chocolate Trial in celebration of International Clinical Trials Day 2017!  The Research Department and Library & Knowledge Service will be co-hosting this fun event to highlight the importance of research in healthcare and to help participants understand how clinical trials work. 
Friday 19th May 2017
Seminar Rooms A/B, Clinical Skills, Arrowe Park
Drop in any time between 12pm and 2pm
No need to book, just turn up – and bring your colleagues with you.  The results of our trial will be published after the study.  All participants will be entered into a free prize draw to win… more chocolate!

Wednesday 26 April 2017

McArdle Library

Please note that the McArdle Library will be staffed until 5.00 p.m. on  Friday 28/4/17 and will next be staffed on Tuesday 2/5/17. 24 hour access is currently not available but we hope to have a resolution soon.

Wednesday 19 April 2017

New e-books for all WUTH staff

New e-books for all WUTH staff

All WUTH Athens account holders now have access to Community and Public Health titles including:

·        Public Health and Epidemiology at a Glance from the hugely popular ‘At A Glance’ series

·        Health communication : from theory to practice - introduces existing challenges and areas of interest in health communication

·        The Routledge Handbook of Planning for Health and Well-Being  - case studies of good practice from around the globe.

You can access these titles and more from the Library & Knowledge Service catalogue. http://arrowe.cirqahosting.com/
 All you need is your Open Athens account.
Contact the Library and Knowledge Service for details on accessing the catalogue and registering for an Open Athens account.

Wednesday 12 April 2017

WUTH publication: Avoiding Radical Surgery in Elderly Patients With Rectal Cancer Is Cost-Effective

Citation: Diseases of the colon and rectum. 2017, 60(1), 30-42
Author: Rao C, Sun Myint A, Athanasiou T, Faiz O, Martin AP, Collins B, Smith FM
Abstract: BACKGROUND: Radical surgery is associated with significant perioperative mortality in elderly and comorbid populations. Emerging data suggest for patients with a clinical complete response after neoadjuvant chemoradiotherapy that a watch-and-wait approach may provide equivalent survival and oncological outcomes.
OBJECTIVE: The purpose of this study was to compare the cost-effectiveness of watch and wait and radical surgery for patients with rectal cancer after a clinical complete response following chemoradiotherapy.
DESIGN: Decision analytical modeling and a Markov simulation were used to model long-term costs, quality-adjusted life-years, and cost-effectiveness after watch and wait and radical surgery. Sensitivity analysis was used to investigate the effect of uncertainty in model parameters.
SETTINGS: A third-party payer perspective was adopted.
PATIENTS: Patients included in the study were a 60-year-old male cohort with no comorbidities, 80-year-old male cohorts with no comorbidities, and 80-year-old male cohorts with significant comorbidities.
INTERVENTIONS: Radical surgery and watch-and-wait approaches were studied.
MAIN OUTCOME MEASURES: Incremental cost, effectiveness, and cost-effectiveness ratio over the entire lifetime of the hypothetical patient cohorts were measured.
RESULTS: Watch and wait was more effective (60-year-old male cohort with no comorbidities = 0.63 quality-adjusted life-years (95% CI, 2.48-3.65 quality-adjusted life-years); 80-year-old male cohort with no comorbidities = 0.56 quality-adjusted life-years (95% CI, 0.52-1.59 quality-adjusted life-years); 80-year-old male cohort with significant comorbidities = 0.72 quality-adjusted life-years (95% CI, 0.34-1.76 quality-adjusted life-years)) and less costly (60-year-old male cohort with no comorbidities = $11,332.35 (95% CI, $668.50-$23,970.20); 80-year-old male cohort with no comorbidities = $8783.93 (95% CI, $2504.26-$21,900.66); 80-year-old male cohort with significant comorbidities = $10,206.01 (95% CI, $2762.014-$24,135.31)) independent of patient cohort age and comorbidity. Consequently, watch and wait was more cost-effective with a high degree of certainty (range, 69.6%-89.2%) at a threshold of $50,000/quality-adjusted life-year.
LIMITATIONS: Long-term outcomes were derived from modeled cohorts. Analysis was performed for a United Kingdom third-party payer perspective, limiting generalizability to other healthcare contexts.
CONCLUSIONS: Watch and wait is likely to be cost-effective compared with radical surgery. These findings strongly support the discussion of organ-preserving strategies with suitable patients.

Link to PubMed record

Tuesday 11 April 2017

Easter Opening Times

The Library & Knowledge Service will close
at 5pm on Thursday 13th April
and re-open
at 9am on Tuesday 18th April 2017

Unfortunately 24-Hour access is not currently available.
Apologies for any inconvenience this may cause.
During this period, please send any queries to mcardle.library@nhs.net
and we will get back to you after the Easter break.​​

Monday 10 April 2017

WUTH publication: Opioid-induced myoclonus and hyperalgesia following a short course of low-dose oral morphine

Citation: British Journal of Pain. 2017, 11(1), 32-35
Author: Woodward OB, Naraen S, Naraen A
Abstract: A 76-year-old man was admitted to hospital with a right-sided fractured neck of femur requiring repair via a cemented hemiarthroplasty. Intraoperatively he received 10 mg of intravenous morphine. Post-operatively he received a short course of low-dose oral opioids and subsequently developed myoclonic jerks and hyperalgesia. The opioids were discontinued and both adverse effects resolved. This case report discusses the concurrent development of myoclonus and hyperalgesia following a low dose of opioids and explores possible management options.
KEYWORDS: Pain perception; adverse effect; hyperalgesia; myoclonus; opioid

Link to PubMed record