Citation: International Wound Journal. Int Wound J. 2016 Aug;13(4):442-8. Epub 2015 Jun 21.
Author: Harding KG, Szczepkowski M, Mikosiński J, Twardowska-Saucha K, Blair S, Ivins
NM, Saucha W, Cains J, Peters K, Parsons D, Bowler P
Abstract: The objective of this study was to investigate the safety and performance of
AQUACEL™ Ag+ dressing, a wound dressing containing a combination of anti-biofilm
and antimicrobial agents, in the management of chronic wounds. Patients (n = 42)
with venous leg ulcers exhibiting signs of clinical infection were treated for 4
weeks with AQUACEL™ Ag+ dressing, followed by management with AQUACEL™ wound
dressings for 4 weeks. Wound progression, wound size, ulcer pain and clinical
evolution of the wound were assessed for up to 8 weeks. Adverse events were
recorded throughout the study. AQUACEL™ Ag+ dressing had an acceptable safety
profile, with only one patient discontinuing from the study, because of a
non-treatment-related adverse event. After 8 weeks, substantial wound
improvements were observed: 5 patients (11·9%) had healed ulcers and 32 patients
(76·2%) showed improvement in ulcer condition. The mean ulcer size had reduced
by 54·5%. Patients reported less pain as the study progressed. Notable
improvements were observed in patients with ulcers that were considered to
require treatment with systemic antibiotics or topical antimicrobials at
baseline (n = 10), with a mean 70·2% reduction in wound area. These data
indicate that AQUACEL™ Ag+ dressing has an acceptable safety profile in the
management of venous leg ulcers that may be impeded by biofilm.
Link to PubMed record
