Citation: Comment on 'Herpes zoster ophthalmicus reduction: implementation of
shingles vaccination in the UK'.
Eye (Lond). 2014 Dec;28(12):1522-3
Authors: Clearkin L
PMID: 25190531 [PubMed - indexed for MEDLINE]
Link to Pubmed record
Monday, 25 May 2015
Monday, 18 May 2015
WUTH Publication: Altered cortical processing of observed pain in fibromyalgia syndrome patients.
Citation: Altered cortical processing of observed pain in fibromyalgia syndrome
patients.
J Pain. 2015 May 12;
Authors: Fallon N, Li X, Chiu Y, Nurmikko T, Stancak A
Abstract: Fibromyalgia syndrome (FMS) is characterised by widespread chronic pain, fatigue, sleep disorders and cognitive-emotional disturbance. FMS patients exhibit increased sensitivity to experimental pain and pain-related cues, as well as deficits in emotional regulation. The present study investigated the spatio-temporal patterns of brain activations for observed pain in 19 FMS patients and 18 age-matched, healthy control subjects using event-related potential (ERP) analysis. Fibromyalgia patients attributed greater pain and unpleasantness to pain pictures relative to healthy control participants. An augmented late positive potential (LPP) component (>500 ms) was found in patients during both pain and non-pain pictures, and this amplitude difference in the LPP covaried with perceived unpleasantness of pictures. Mid-latency potentials (250-450 ms) demonstrated similar amplitude increases of positive potentials in the FMS patient group. By contrast, the short-latency positive potential (140 ms) was reduced in FMS patients relative to healthy control participants. Results suggest amplitude increases to mid-long latency cortical activations in FMS patients, which are known to reflect emotional control and motivational salience of stimuli.
PERSPECTIVE: FMS patients demonstrate increased activations for pain and non-pain pictures. The findings suggest that even innocuous, everyday visual stimuli with somatic connotations may challenge the emotional state of FMS patients. Our study points towards the importance of cognitive-emotional therapeutic approaches for the treatment of FMS.
PMID: 25979860 [PubMed - as supplied by publisher]
Link to Pubmed record
J Pain. 2015 May 12;
Authors: Fallon N, Li X, Chiu Y, Nurmikko T, Stancak A
Abstract: Fibromyalgia syndrome (FMS) is characterised by widespread chronic pain, fatigue, sleep disorders and cognitive-emotional disturbance. FMS patients exhibit increased sensitivity to experimental pain and pain-related cues, as well as deficits in emotional regulation. The present study investigated the spatio-temporal patterns of brain activations for observed pain in 19 FMS patients and 18 age-matched, healthy control subjects using event-related potential (ERP) analysis. Fibromyalgia patients attributed greater pain and unpleasantness to pain pictures relative to healthy control participants. An augmented late positive potential (LPP) component (>500 ms) was found in patients during both pain and non-pain pictures, and this amplitude difference in the LPP covaried with perceived unpleasantness of pictures. Mid-latency potentials (250-450 ms) demonstrated similar amplitude increases of positive potentials in the FMS patient group. By contrast, the short-latency positive potential (140 ms) was reduced in FMS patients relative to healthy control participants. Results suggest amplitude increases to mid-long latency cortical activations in FMS patients, which are known to reflect emotional control and motivational salience of stimuli.
PERSPECTIVE: FMS patients demonstrate increased activations for pain and non-pain pictures. The findings suggest that even innocuous, everyday visual stimuli with somatic connotations may challenge the emotional state of FMS patients. Our study points towards the importance of cognitive-emotional therapeutic approaches for the treatment of FMS.
PMID: 25979860 [PubMed - as supplied by publisher]
Link to Pubmed record
Friday, 15 May 2015
WUTH Publication: Epithelioid haemangioma: a rare cause of painful erections and sleep deprivation.
Ciation: Epithelioid haemangioma: a rare cause of painful erections and sleep
deprivation.
Int Urol Nephrol. 2014 Sep;46(9):1747-50
Authors: Lucky MA, McGuinness LA, Floyd MS, Azhar U, Shanks JH, Li C, Shenjere P, Nonaka D, Robinson LQ, Parr NJ
Abstract: Epithelioid haemangioma of the penis is a rare condition which usually presents a solid single nodule. We report a case in a 43-year-old man who presented with painful erections and sleep disturbance with two palpable penile nodules. Magnetic resonance imaging with an artificially induced erection revealed these as individual lesions, and local excision was successfully undertaken. Pathological diagnosis of epithelioid haemangioma was confirmed with positive staining for CD31. Although rare, penile epithelioid haemangioma should be considered as a differential in an atypical penile mass. Induction in of an artificial erection prior to MRI can aid diagnosis and treatment is typically with surgical excision.
PMID: 24682864 [PubMed - indexed for MEDLINE]
Link to Pubmed record
Int Urol Nephrol. 2014 Sep;46(9):1747-50
Authors: Lucky MA, McGuinness LA, Floyd MS, Azhar U, Shanks JH, Li C, Shenjere P, Nonaka D, Robinson LQ, Parr NJ
Abstract: Epithelioid haemangioma of the penis is a rare condition which usually presents a solid single nodule. We report a case in a 43-year-old man who presented with painful erections and sleep disturbance with two palpable penile nodules. Magnetic resonance imaging with an artificially induced erection revealed these as individual lesions, and local excision was successfully undertaken. Pathological diagnosis of epithelioid haemangioma was confirmed with positive staining for CD31. Although rare, penile epithelioid haemangioma should be considered as a differential in an atypical penile mass. Induction in of an artificial erection prior to MRI can aid diagnosis and treatment is typically with surgical excision.
PMID: 24682864 [PubMed - indexed for MEDLINE]
Link to Pubmed record
WUTH Publication: Localised amyloidosis of the glans penis presenting as a painless lump with progression after 10 years.
Citation: Localised amyloidosis of the glans penis presenting as a painless lump
with progression after 10 years.
Int Urol Nephrol. 2014 Sep;46(9):1737-9
Authors: Floyd MS, Glendinning J, Hiew K, Avram AM, Seneviratne R, Parr NJ
Abstract: Primary amyloidosis of the genitourinary tract is uncommon, and isolated invasion of the glans penis is exceptionally rare Degos et al. (Bull Soc Fr Dermatol Syphiligr 68:159, 1961). We report a case of localised amyloidosis of the glans penis in a 40-year-old presenting as an asymptomatic penile mass which changed after 10 years prompting treatment. We believe this to be the longest interval recorded between clinical occurrence and histological diagnosis of primary penile amyloidosis.
PMID: 24906425 [PubMed - indexed for MEDLINE]
Link to Pubmed record
Int Urol Nephrol. 2014 Sep;46(9):1737-9
Authors: Floyd MS, Glendinning J, Hiew K, Avram AM, Seneviratne R, Parr NJ
Abstract: Primary amyloidosis of the genitourinary tract is uncommon, and isolated invasion of the glans penis is exceptionally rare Degos et al. (Bull Soc Fr Dermatol Syphiligr 68:159, 1961). We report a case of localised amyloidosis of the glans penis in a 40-year-old presenting as an asymptomatic penile mass which changed after 10 years prompting treatment. We believe this to be the longest interval recorded between clinical occurrence and histological diagnosis of primary penile amyloidosis.
PMID: 24906425 [PubMed - indexed for MEDLINE]
Link to Pubmed record
WUTH Publication: Critical care in the emergency department: acute kidney injury.
Citation: Critical care in the emergency department: acute kidney injury.
Emerg Med J. 2016, 33(5), 361-5
Authors: Nee PA, Bailey DJ, Todd V, Lewington AJ, Wootten AE, Sim KJ
Abstract: Acute kidney injury (AKI) is common among emergency department patients admitted to hospital. There is evidence of inadequate management of the condition leading to adverse outcomes. We present an illustrative case of AKI complicating a gastrointestinal disorder in an older adult. We discuss the clinical presentation, assessment and management of AKI with reference to recent consensus guidelines on classification and treatment.
PMID: 25969433 [PubMed - as supplied by publisher]
Link to Pubmed record
Emerg Med J. 2016, 33(5), 361-5
Authors: Nee PA, Bailey DJ, Todd V, Lewington AJ, Wootten AE, Sim KJ
Abstract: Acute kidney injury (AKI) is common among emergency department patients admitted to hospital. There is evidence of inadequate management of the condition leading to adverse outcomes. We present an illustrative case of AKI complicating a gastrointestinal disorder in an older adult. We discuss the clinical presentation, assessment and management of AKI with reference to recent consensus guidelines on classification and treatment.
PMID: 25969433 [PubMed - as supplied by publisher]
Link to Pubmed record
Wednesday, 13 May 2015
Oxford Medical Handbooks are available to all WUTH staff and
learners. The collection is available online, meaning that you don’t need to
come in to the library to use it.
The Handbooks offer a convenient way for medical and nursing
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on your topic, please go to NICE Evidence at www.evidence.nhs.uk and select ‘Journals and databases’. For
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